669-Single-Cell Landscapes of Olfactory Neuroblastoma
This research article from Nature Cancer details a comprehensive study of olfactory neuroblastoma (ONB) using single-cell RNA sequencing to map its complex cellular landscape. By analyzing thousands of individual cells, researchers identified intra-tumoral heterogeneity and established a new tripartite classification system consisting of neural, basal, and mesenchymal subtypes. The study reveals that these distinct molecular profiles originate from different lineages within the olfactory epithelium, such as globose and horizontal basal cells. These findings are clinically significant as they…
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