128-Cancer-induced nerve injury Drives Anti-PD-1 Resistance
This paper details extensive research on how cancer-induced nerve injury (CINI) promotes resistance to anti-PD-1 immunotherapy. The study employed a variety of methods, including multiomics analysis of human patient cohorts with various cancers like cutaneous squamous cell carcinoma (cSCC), metastatic melanoma, and gastric cancer, alongside in vivo mouse models and in vitro co-culture assays involving neurons and cancer cells. Key findings suggest that cancer cells cause myelin degradation, leading to nerve injury, which triggers inflammatory pathways, specifically involving IFN-I and IL-6…
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