1346-Competing Programs of Cortical Sensorimotor Axis

Paper Talk · Jul 28, 2026 · 12m

This research introduces the MIND model, a new framework explaining how the cerebral cortex develops its functional organization along the sensorimotor-to-association (S–A) axis. The study identifies two competing genetic programs: "pericentral" programs that promote high-order association networks from the brain's poles and "central" programs that establish primary sensory and motor areas. These programs interact through a process of induction and exclusion, where sensory inputs from the thalamus trigger the formation of primary areas that effectively push out association identities. This…