094-DOLPHIN: Using RNA splicing to enhance ScRNA analysis

Paper Talk · Sep 28, 2025 · 23m

This paper introduces DOLPHIN, a novel deep learning framework designed to enhance single-cell RNA sequencing (scRNA-seq) analysis by moving beyond traditional gene-level quantification. The researchers explain that conventional methods often overlook crucial exon-level information and junction reads, which limits the accurate representation of cellular states. DOLPHIN integrates these detailed genomic elements by modeling genes as graph structures and processing them with a variational graph autoencoder to create superior cell embeddings. The text details how this approach significantly…