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Cancer Clinical Trials: Benefits to Patients and Society · Talking FACS

• 0:01
  Welcome to talking facts and thank you for tuning in to cancer conversations on talking facts.
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  A podcast collaboration between the University of Kentucky,
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  Markey Cancer Center and the U.
• 0:11
  K.
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  College of Agriculture,
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  food and environments.
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  Cooperative Extension service.
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  We will share with you the latest developments in cancer prevention,
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  diagnosis,
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  treatment and research from the experts at Markey Cancer Center,
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  Kentucky's only National Cancer Institute designated cancer center.
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  Talking facts is hosted by the U.
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  K.
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  Family and Consumer Sciences extension program.
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  Our educators share research knowledge with individuals,
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  families and communities to improve quality of life.
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  Hello and welcome to cancer conversations on talking facts.
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  This is your host,
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  DR Jennifer Hunter,
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  assistant director for Family Consumer Sciences extension at the University of Kentucky.
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  Today,
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  I'm pleased to be joined by DR Howell,
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  a professor of medicine and cancer biology in the UK.
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  Markey Cancer Center.
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  Welcome Dr How?
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  Thank you DR Hunter.
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  So today's topic is one that I think folks sometimes have just will find of interest and intrigue.
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  But we're going to talk about cancer clinical trials and how they benefit patients as well as how they benefit society in general.
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  I think that that's something that folks like to understand more just because we hear about clinical trials from a research base or from a scientific base.
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  But today we're really going to talk about how clinical trials work and as well as the benefits of them.
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  So let's start with the question of what is a cancer clinical trial.
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  Great cancer clinical trial is a research studies participated by human volunteers diagnosed with his cancer clinical trials.
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  often Designed as different faces.
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  For example,
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  Phase one through 3 different trial faces.
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  You really have different objectives.
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  They are designed to learn more about effects of intervention with a drug,
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  a drug combination on cancer patients or on cancer.
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  For example,
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  they face one clinical trial.
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  All the studies,
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  whether a drug or drug combination or device is safe to give to human Phase three trials often studies whether a drug or drug combination is more effective compared to a current standard of care in various stage of cancer these days,
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  early phase clinical trials involving molecular targeted drugs can hint efficacy very clearly early.
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  The decision to launch a clinical trial is usually based on previous evidence or hints obtained from laboratories or from animal studies.
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  Later based clinical trials are documented or conducted when early phase clinical trials show our intervention was safe and may be effective in humans.
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  Clinical trials are conducted by a study team consistent of investigator,
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  coordinator among other staff members.
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  The doctor in charge of the study is called a principal investigator.
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  The study is conducted strictly following a steady protocol written beforehand.
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  No division is allowed to ensure reliable conclusion.
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  A simple question and maybe the answer is obvious,
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  but why are clinical trials necessary?
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  Right clinical trial to test the hypothesis to put them forward by a researcher.
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  For example,
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  they say also merchandise or take Rezo by brand name.
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  Can control 87 90 M Baron non small cell lung cancer.
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  The results are used to approve or disapprove the hypothesis based on carefully designed and executed clinical studies.
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  When trials turn out to be positive,
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  that means the hypothesis is proven and that it will work in the real world beyond reasonable doubts.
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  Since the evidence showed in the trial is unlikely obtained by chance in the medical field,
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  we practice evidence based medicine.
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  So clinical trials are designed to produce evidence showing intervention works all standard of care today is derived from yesterday's positive clinical trial results.
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  Therefore,
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  clinical trials are necessary to improve today's care and discover more effective treatments or interventions and perfect them for tomorrow's patient care.
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  So,
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  as you talk about the idea that today's clinical trials are making tomorrow's patient care better.
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  How specifically do patients and society benefit from participating with clinical trials?
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  That's a good question.
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  I think participants can think from the following perspectives if clinical trial is for you and then if you believe one of the following.
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  For example,
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  trial participation allows you to play an active role in your own healthcare and you choose the way you are treated two.
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  You may want to gain access to new research treatment before they are widely available.
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  Clinical trial may be the only way you will be able to access.
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  Thirdly,
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  clinical trial participation increases the options for treatment when standard care therapy has failed.
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  Also,
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  most clinical trials are conducted in tertiary care referral centers.
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  So one can obtain expert medical opinion or care or the best supportive care at the leading health care facility during the trial,
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  when they are monitored by the study team closely.
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  Alternatively,
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  enrollment into clinical trial may help others by contributing to the advancement of medical knowledge.
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  Remember again,
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  today's standard of care was yesterday's clinical trial.
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  I really liked that thought.
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  And you know,
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  as I'm thinking about clinical trials and if as a patient,
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  I've been approached with an opportunity to participate in a clinical trial,
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  will that cost me?
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  Does that or it may not be in all instances,
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  but typically would the patient have to pay additional for that care?
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  Great question.
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  You don't need to pay more than you should for standard care.
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  Since the standard care is paid by insurance and research cost is covered by the study sponsor.
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  So now let me ask the question the opposite way will I be paid to participate in the clinical trial.
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  Normally clinical trials do not pay participants occasionally.
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  However,
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  there is incentives from the study but RB or have to approved this a few minutes ago,
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  you mentioned about one of the benefits of clinical trials is allowing a patient to gain access to new research treatments that may not be otherwise available or maybe they've exhausted other types of treatments or therapies and this.
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  This is an additional opportunity for them.
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  How does the patient become eligible for a clinical trial participants are screened against the inclusion and exclusion criteria listed in the protocol.
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  One must meet all the inclusion criteria and not excluded by any of the exclusion criteria in the protocol.
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  So what happens if someone signs up for a protocol and they decide that they would like to withdraw?
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  Is that something that they can do from a clinical trial?
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  Absolutely participating can withdraw anytime,
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  No reason needed them.
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  So we talked about the upsides and the benefits of participating in a clinical trial.
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  But is there a downside?
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  Yes,
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  you can think that way.
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  Um there is no guarantee.
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  100% guarantee the drug being tested will work.
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  But to be fair,
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  even the standard of care,
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  there is no 100% guarantee.
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  And besides then,
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  12 participation you really needs more efforts from the participants compared to when they received the standard of care.
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  DR hall Thank you so much for joining us today for our listeners that may be interested in just additional information regarding cancer as well as additional information regarding clinical trials.
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  You've provided several links that we will add to our show notes if someone is interested in following up an additional detail.
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  Thank you for joining us today.
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  Thank you so much.
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  Dr hunter for human being this opportunity.
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  Wonderful,
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  thank you for listening to cancer conversations on talking facts.
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  Our goal is to connect you with the latest advances in cancer research in the commonwealth.
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  If you enjoyed today's podcast and have a suggestion for a future show topic,
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  please message us on the UK Markey Cancer Center facebook page at facebook dot com forward slash UK marquee or visit our website at marquee dot u k y dot e d u.
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  For more information,
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  you can find University of Kentucky,
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  family and consumer sciences extension programs at your local extension office or online at FCS dot u k y dot e d u Building strong families building Kentucky.
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  It starts with us.
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  Yes.