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Latest / The Hunter Williams Podcast

The NAD+ Masterclass | A Research Guide (2026)

NAD+ is not a peptide. That one fact changes how you should use it.Peptides send a signal. NAD+ is a coenzyme, meaning it does the work itself. There is no receptor to downregulate, so the cycling logic is completely different.In this one I walk through what NAD+ actually does inside the cell, what burns through it, and whether it really crashes with age. The decline is real. It is just far more modest and tissue specific than the biohacking world tells you. Skin drops hard. Brain drops 10 to 13 percent across a lifetime. Liver and muscle barely move at all.I also get into the uncomfortable…

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