884-Two Neurons Drive Brainwide Blood Volume Changes
This study investigates how brainwide blood volume relates to neuronal activity in mice, revealing that neurovascular coupling is more complex than previously thought. Using functional ultrasound imaging and Neuropixels recordings, the authors discovered that blood flow is not just a reflection of bulk neural activity but is driven by two opposing neural populations. One group of neurons increases activity during arousal events like whisking, while the other group decreases activity; notably, these two populations possess distinct hemodynamic response functions. This dual-population model…
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