792-Spatiotemporal Modeling of Molecular Holograms
The paper introduce Spateo, a versatile computational framework designed for the 3D spatiotemporal modeling of various spatial transcriptomics datasets. By applying this toolkit to a massive atlas of mouse and Drosophila embryos, researchers can reconstruct "molecular holograms" that capture millions of cells in their precise physical context. The software features advanced algorithms for non-rigid alignment, 3D digitization of complex structures, and the mapping of cell-cell interactions across organ-scale distances. A key innovation is the creation of morphic vector fields, which allow…
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