Rethinking Polio
Rethinking Polio by Forrest Maready at Brownstone Institute Abstract The prevailing understanding of poliovirus pathogenesis posits that the virus, following intestinal infection, gains access to the central nervous system (CNS) through viremia and subsequent crossing of the blood-brain barrier (BBB). However, this model fails to adequately explain several key epidemiological and clinical features of the historical polio epidemic, including the localized nature of paralysis, the disproportionate involvement of the lower limbs, the increased susceptibility of young children, and the striking…
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