535-Neural Dynamics in compulsive behavioral
Research identifies low-gamma power in the anteromedial orbitofrontal cortex (amOFC) as a biomarker for OCD distress. Stimulating the ventral basal ganglia (NAc-VeP) reduces this neural activity and alleviates symptoms, supporting personalized, closed-loop deep brain stimulation.
References:
Nho Y H, Qiu L, Seilheimer R L, et al. Human orbitofrontal neural activity is linked to obsessive-compulsive behavioral dynamics[J]. Cell, 2026.
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