1251-Ovarian Spatiotemporal Atlas of Folliculogenesis

Paper Talk · Jul 9, 2026 · 21m

This study utilizes Slide-seq, a high-resolution spatial transcriptomics technique, to map the complex cellular landscape of the mouse ovary throughout its life cycle. Researchers developed a specialized segmentation pipeline to analyze the molecular interactions between oocytes, follicles, and corpora lutea across young and aging biological samples. The data reveal that chronological aging causes a significant breakdown in the spatiotemporal coordination of ovarian structures, even before reproductive cycles officially end. These age-related changes are marked by heightened inflammation…