Latest / Do You F*cking Mind? / Brain Fact: L-Theanine in Matcha

Transcript

Brain Fact: L-Theanine in Matcha · Do You F*cking Mind?

• 0:12
  Speaker 1: I have a brain factor.
• 0:14
  Speaker 2: Now, full disclosure, this is a brain factor that I
• 0:17
  Speaker 2: have done in the past, but I wanted to add
• 0:19
  Speaker 2: a little bit more into it because we're talking about
• 0:22
  Speaker 2: l f andine, and lfanine is something that well, I'm
• 0:26
  Speaker 2: going to talk about it in a second. But one
• 0:28
  Speaker 2: thing that I didn't really mention in the last time
• 0:30
  Speaker 2: that I spoke about l f andine was how much
• 0:33
  Speaker 2: lfa andine is in maucha. I did mention about green
• 0:36
  Speaker 2: tea and different types of green tea, but I want
• 0:39
  Speaker 2: to specifically talk about macha and why maucha is such
• 0:42
  Speaker 2: a great source of l anine versus other also really
• 0:47
  Speaker 2: good sources.
• 0:47
  Speaker 1: Okay, So the brain factor of today is basically l fanine.
• 0:51
  Speaker 1: So what is it?
• 0:53
  Speaker 2: How does it affect the brain, How does it alleviate stress,
• 0:57
  Speaker 2: its implications on mood disorders, How it affects anxiety, It
• 1:02
  Speaker 2: can also assist with sleep.
• 1:04
  Speaker 1: So what is it?
• 1:05
  Speaker 2: Basically, it's a naturally occurring non protein amino acid, and
• 1:10
  Speaker 2: it is found in very high quantities in green tea,
• 1:14
  Speaker 2: in all different kinds of green tea. Okay, Now, the
• 1:18
  Speaker 2: reason why it's such an interesting amino.
• 1:20
  Speaker 1: Acid, why a lot of people.
• 1:21
  Speaker 2: You might hear a lot of people banging on about
• 1:23
  Speaker 2: why you should be taking althenine is because of these
• 1:26
  Speaker 2: amazing effects that it has on the brain, not just
• 1:29
  Speaker 2: on human brains, but you see it in a lot
• 1:31
  Speaker 2: of studies on rat models and in mice models as well.
• 1:35
  Speaker 2: I was about to say, in rice models, rat and
• 1:37
  Speaker 2: mice models. So it's pretty cool all the benefits that
• 1:41
  Speaker 2: your brain will get from consuming elthenanine. And I'm going
• 1:44
  Speaker 2: to talk about a study that was done as well,
• 1:49
  Speaker 2: and hopefully it will inspire you to get amongst it.
• 1:52
  Speaker 1: And if you're someone that's like I've tried much, I'm
• 1:55
  Speaker 1: not about it. It is not.
• 1:57
  Speaker 2: Fucking it for me, then green tea is still sensational
• 2:02
  Speaker 2: for you and for your brain. Okay, you'll be wanting
• 2:05
  Speaker 2: to fucking drink a cup of much of green tea daily,
• 2:08
  Speaker 2: if not twice a day after listening to this, So.
• 2:10
  Speaker 1: Basically, let's talk about it. The molecular structure. I fucking
• 2:14
  Speaker 1: love molecules so much.
• 2:15
  Speaker 2: I love talking about molecules and molecular structure and drugs
• 2:18
  Speaker 2: and pharmacology and all that shit.
• 2:19
  Speaker 1: So this is right at my alley.
• 2:20
  Speaker 2: The molecular structure of L thanine is very close to
• 2:23
  Speaker 2: that of L glutamic acid. So it's believed that this
• 2:28
  Speaker 2: lthenine performs its actions and is basically mediated via glutamate receptors. Okay,
• 2:35
  Speaker 2: so I'm gonna speak about gabone glutamate in a little
• 2:38
  Speaker 2: bit more depth, but basically it acts on the same
• 2:41
  Speaker 2: receptors that this L glutamic acid acts on because of
• 2:45
  Speaker 2: its molecular structure, that's all you need to really think about.
• 2:48
  Speaker 2: And what's happening is that it's also competing at this
• 2:51
  Speaker 2: at the binding site where glutamate binds too. Okay, now
• 2:55
  Speaker 2: I've spoken about glutamate a thousand times. Glutamate is the
• 2:59
  Speaker 2: major citatory neurotransmitter within the brain versus GABBA, which is
• 3:04
  Speaker 2: the major inhibitory neurotransmitter. So excitation, we're seeing more activity
• 3:09
  Speaker 2: in the brain. Whether it's good or bad, it's just
• 3:11
  Speaker 2: more activity. More synaps is more firing, just more, and
• 3:17
  Speaker 2: then inhibition is using a reduction in excitability or excitation
• 3:22
  Speaker 2: within the brain.
• 3:23
  Speaker 1: Okay.
• 3:25
  Speaker 2: So another good thing about the molecular structure of lthnine
• 3:30
  Speaker 2: is that it is based on its shape and structure,
• 3:32
  Speaker 2: it is able to cross the blood brain barrier. So
• 3:36
  Speaker 2: it has really really strong effects within the central nervous system.
• 3:39
  Speaker 2: And remember the central nervous system is your brain, brain stem,
• 3:42
  Speaker 2: and spinal cord. Okay, so anything that can cross the
• 3:44
  Speaker 2: blood brain barrier, you're getting those effects in the central
• 3:48
  Speaker 2: nervous system, which is in this scenario great. Another thing
• 3:52
  Speaker 2: that it can do is it can block glutamate receptors
• 3:54
  Speaker 2: within the central nervous system. And when it's blocking or
• 3:57
  Speaker 2: when it's kind of modulating or modifying what's going on
• 4:00
  Speaker 2: it the glutamate receptor, you're getting this limitation of excitability.
• 4:04
  Speaker 2: You're not stopping excitability altogether, that's just an insurmountable task.
• 4:10
  Speaker 2: You pretty much have to knock someone out for that
• 4:12
  Speaker 2: to happen, but you are limiting this excitability.
• 4:15
  Speaker 1: All right.
• 4:15
  Speaker 2: So a lot of different mood disorders, depression, anxiety, it's
• 4:23
  Speaker 2: got to do with excitability and inhibition. Okay, you're seeing
• 4:27
  Speaker 2: there's either too much excitability or a dysregulation in excitability.
• 4:31
  Speaker 1: So when you look at different.
• 4:33
  Speaker 2: Drugs that target depression for example, or anxiety for example,
• 4:38
  Speaker 2: you're looking at different theories, and you've got like the
• 4:41
  Speaker 2: monoamine theory, which is the drugs that target things like
• 4:45
  Speaker 2: serotonin and dopamine and chemicals like that.
• 4:49
  Speaker 1: But then you've got the kind of.
• 4:55
  Speaker 2: Glutamate hypothesis, which is where you're using drugs such as
• 4:58
  Speaker 2: ketamine to target kind of the glutamate pathway or the
• 5:03
  Speaker 2: idea that glutamate might be behind all.
• 5:05
  Speaker 1: These different mood disorders. So here we're seeing.
• 5:07
  Speaker 2: Something that is a modulator or modifying what's going on
• 5:10
  Speaker 2: at the glutamate receptor in the form of l panine,
• 5:13
  Speaker 2: which you can have in a t that can also
• 5:15
  Speaker 2: have similar effects in modulating this amount of excitability within
• 5:20
  Speaker 2: the brain. Okay, so we're seeing that lthanine can do
• 5:25
  Speaker 2: that with glutamate. It can also exert its effects on
• 5:27
  Speaker 2: GABBA receptors, which.
• 5:28
  Speaker 1: Enhance says GABBA activity.
• 5:31
  Speaker 2: And because of this enhancement of GABA activity, it's also
• 5:33
  Speaker 2: helping increase dopamine and serotonin because dopamine and serotonin are linked.
• 5:38
  Speaker 1: To activity with GABBA as well.
• 5:40
  Speaker 2: Okay, so lthanine it's not a sedative, it's not going
• 5:44
  Speaker 2: to cause sleepiness, it's not going to cause drowsiness. It
• 5:49
  Speaker 2: just allows the body to be in a more relaxed
• 5:52
  Speaker 2: state in general. Because of its effects on GABBA and
• 5:55
  Speaker 2: glutamate fucking epic. Okay, So we want to look at lthane,
• 6:00
  Speaker 2: this amino acid as being a neuromodulator. It's basically modulating
• 6:05
  Speaker 2: the levels of neurotransmitters so helps bring you into this nice, calm,
• 6:09
  Speaker 2: relaxed state, and therefore it is conducive to overall better sleep.
• 6:13
  Speaker 2: So if you're increasing your levels of elthenine, it is
• 6:16
  Speaker 2: helping you later on in the day with sleep, okay.
• 6:22
  Speaker 2: And it's obviously not making you drowsy, it's just making
• 6:25
  Speaker 2: you more relaxed. Now, it's not endogenously produced, which means
• 6:29
  Speaker 2: that it is not made by your own body. It
• 6:31
  Speaker 2: can't be produced by your own body, so endogenous versus exogenous.
• 6:36
  Speaker 2: But it's not an essential amino acid, so we don't
• 6:39
  Speaker 2: need it to survive.
• 6:40
  Speaker 1: So an essential.
• 6:41
  Speaker 2: Amino acid, I've spoken about this before, is something that
• 6:43
  Speaker 2: you need to survive, but you can't make it with
• 6:45
  Speaker 2: your own body, so you need it from your diet.
• 6:48
  Speaker 2: This is not essential, although I think it should be essential,
• 6:50
  Speaker 2: but it's not essential for your survival all right. Now,
• 6:54
  Speaker 2: where do you get it? It's found in many sources,
• 6:57
  Speaker 2: but it's believed that the highest quantity is not other
• 7:00
  Speaker 2: than because you can get it in supplements as well,
• 7:01
  Speaker 2: which you'll speak about in a second, but is the
• 7:04
  Speaker 2: highest is in green tea. So macha is when it
• 7:08
  Speaker 2: comes to elthanine, going to be the most superior source
• 7:12
  Speaker 2: of elthenine versus other kinds of green tea. Mucha can
• 7:16
  Speaker 2: contain up to five times more than other kinds of
• 7:21
  Speaker 2: green tea, five times more elthanine than other kinds of
• 7:23
  Speaker 2: green tea. And the reason for this is because Mucha,
• 7:28
  Speaker 2: the mucha tea grows in the shade, okay, and the shade,
• 7:34
  Speaker 2: the role that shade plays in the growth process mitigates
• 7:38
  Speaker 2: this photosynthesis in the leaves, therefore preserving the elthhenine within
• 7:42
  Speaker 2: the leaves among other amino acids as well. Okay, So
• 7:46
  Speaker 2: t's that grow in hectic sunlight are going to have
• 7:49
  Speaker 2: lower levels of elfenin and this is due to oxidization.
• 7:52
  Speaker 1: So that is why macha is just going to be
• 7:55
  Speaker 1: a superior source for lfenin.
• 7:57
  Speaker 2: But if you don't like Mucha, there's still great of
• 8:00
  Speaker 2: the elth and in in regular green tea.
• 8:01
  Speaker 1: It's still very very very good source of elthene in.
• 8:04
  Speaker 1: So do not fret okay now.
• 8:08
  Speaker 2: Also, macha does contain caffeine, but in general it's going
• 8:12
  Speaker 2: to be less than the average cup of coffee. So
• 8:15
  Speaker 2: we're talking about averages here. So on average, in a
• 8:18
  Speaker 2: cup of macha, you're getting roughly seventy milligrams of caffeine
• 8:22
  Speaker 2: versus a cup of coffee you get between one hundred
• 8:25
  Speaker 2: and one hundred and forty milligrams of caffeine in coffee.
• 8:29
  Speaker 1: Okay.
• 8:31
  Speaker 2: You've also got other kinds of green tea, white tea, oo,
• 8:34
  Speaker 2: long tea, and then lower down is black tea, So
• 8:38
  Speaker 2: all the other tea's are going to have higher levels
• 8:40
  Speaker 2: of elthnn before black tea, okay. And then there are
• 8:44
  Speaker 2: some mushrooms as well. I don't know which ones, but
• 8:46
  Speaker 2: there are some mushrooms. Elthanin also has an antioxidant effect
• 8:51
  Speaker 2: on the brain, and we love antioxidants, especially when it's
• 8:55
  Speaker 2: something that can cross the blood brain barrier, like this
• 8:59
  Speaker 2: molecule in elth a enin can okay, So it's very
• 9:03
  Speaker 2: neuroprotective in that matter, it's going to help reduce inflammation.
• 9:06
  Speaker 2: It helps with oxidization within the brain because its targets
• 9:10
  Speaker 2: can be within the central nervous system and its bioavailability
• 9:15
  Speaker 2: is very high.
• 9:16
  Speaker 1: So bioavailability means.
• 9:18
  Speaker 2: How much of this is actually available within your body
• 9:23
  Speaker 2: to exert its effects. That's not being eaten up through
• 9:27
  Speaker 2: digestion and through other things that your body can interfere
• 9:29
  Speaker 2: with when you consume a substance. There are many different
• 9:32
  Speaker 2: vitamins and supplements and minerals on the market that claim
• 9:37
  Speaker 2: all these things, but once you ingest it orally, the
• 9:39
  Speaker 2: bioavailability is just not that great based on how we
• 9:42
  Speaker 2: digest or how our body process. Is that thing lth
• 9:44
  Speaker 2: and in brilliant bioavailability, so it's between seventy two and
• 9:47
  Speaker 2: seventy four percent. It crosses the blood brain barrier within
• 9:52
  Speaker 2: an hour of consumption, and some studies also claim that
• 9:56
  Speaker 2: it might.
• 9:56
  Speaker 1: Aid in ADHD symptoms.
• 9:58
  Speaker 2: Sorry, and also some studies are claiming that it might
• 10:05
  Speaker 2: aid in ADHD symptoms for certain individuals.
• 10:09
  Speaker 1: This is not across the board.
• 10:10
  Speaker 2: It's obviously individual dependent because it is a neuromodulator, so
• 10:14
  Speaker 2: it's helping kind of calm down activity in certain parts
• 10:17
  Speaker 2: of the brain without being a sedative. Based on its
• 10:20
  Speaker 2: effects on the glutamate pathways, You're enhancing dopamine release, You're
• 10:24
  Speaker 2: getting all this regulation of GABBA as well and of glutamate.
• 10:27
  Speaker 1: So it goes a really long way in lowering the.
• 10:29
  Speaker 2: Rate of mood disorders such as depression and anxiety, because,
• 10:34
  Speaker 2: like I mentioned earlier, people with mood disorders are going
• 10:36
  Speaker 2: to have, you know, specific abnormalities in these like two
• 10:40
  Speaker 2: major excitatory and inhibitory neurotransmitters. So also, studies have found
• 10:47
  Speaker 2: that if you pair elphinine with caffeine, it's going to
• 10:50
  Speaker 2: be a really effective way to increase focus during demanding
• 10:54
  Speaker 2: like focus tasks. Okay, so much are green tea? These
• 10:58
  Speaker 2: are really great sources because it's already combined. For you've
• 11:01
  Speaker 2: got your caffeine and you've got your fucking lthan in. Okay,
• 11:04
  Speaker 2: so you're getting this stimulating effect of the caffeine, but
• 11:07
  Speaker 2: you're also getting this alert but calming effect of the
• 11:11
  Speaker 2: l the inin. So basically, go fucking have a much
• 11:15
  Speaker 2: of tea right now, is what I'm trying to get at,
• 11:17
  Speaker 2: or a green tea.
• 11:18
  Speaker 1: If you prefer.
• 11:20
  Speaker 2: And the beauty of it is is that you don't
• 11:22
  Speaker 2: need crazy obscene amounts of caffeine because you've got that
• 11:25
  Speaker 2: combination of the L fenin and of like the smaller
• 11:28
  Speaker 2: amount of caffeine that's in the in the green tea
• 11:31
  Speaker 2: and also in macha. Now I am going to mention
• 11:33
  Speaker 2: a study that I did mention last time that I
• 11:35
  Speaker 2: spoke about this about elthenin and brain fact and the
• 11:39
  Speaker 2: study was done by Shinsuku in twenty nineteen, and it
• 11:43
  Speaker 2: was a randomized placebo controlled crossover.
• 11:46
  Speaker 1: Double blind trial.
• 11:47
  Speaker 2: That is the best, most elite kind of study that
• 11:51
  Speaker 2: you can do, Okay, for many many different reasons. Where
• 11:55
  Speaker 2: you do a double blind means that the researcher and
• 11:59
  Speaker 2: the individual is blinded to if they're getting the place
• 12:01
  Speaker 2: ebo if they're not. Place Ebo controlled means that they're
• 12:04
  Speaker 2: testing the actual substance and they're doing a place ebo
• 12:08
  Speaker 2: and crossover means that every single individual has a certain
• 12:11
  Speaker 2: amount of time with the drug that's being tested or
• 12:14
  Speaker 2: the substance, and then they also have a wash out
• 12:17
  Speaker 2: period and then they're doing a certain period of time
• 12:19
  Speaker 2: with the place ebo, but no one knows which one
• 12:22
  Speaker 2: is what. So this is a very and every participant
• 12:25
  Speaker 2: is trying both. So it's the most superior fucking kind
• 12:29
  Speaker 2: of study that you can do. Obviously, not every kind
• 12:31
  Speaker 2: of study can be done this way, but if you
• 12:32
  Speaker 2: can do it this way, that's ideal. It's also really
• 12:38
  Speaker 2: good at knocking out potential co founding variables and things
• 12:41
  Speaker 2: like that.
• 12:41
  Speaker 1: That's why it's such a good study.
• 12:42
  Speaker 2: So basically it was done to examine what kind of
• 12:44
  Speaker 2: effect four weeks of lth and in administration on stress
• 12:47
  Speaker 2: symptoms and on cognitive function could have on healthy adults.
• 12:51
  Speaker 2: So this study was carried out for over four weeks,
• 12:53
  Speaker 2: but we're looking at the four week effect and it
• 12:56
  Speaker 2: was done on a.
• 12:57
  Speaker 1: Quote unquote healthy population.
• 12:59
  Speaker 2: So what they deemed healthy population to be were people
• 13:02
  Speaker 2: with no psychiatric disorders, but who did suffer from sleep
• 13:07
  Speaker 2: issues and mood and cognitive problems. Because we're trying to
• 13:09
  Speaker 2: look at is it benefiting them or not? Okay, So
• 13:12
  Speaker 2: they were given two hundred milligrams per day of health
• 13:15
  Speaker 2: and In in tablet form, and that's how they did
• 13:18
  Speaker 2: the place ebo control because they didn't know what they
• 13:19
  Speaker 2: were taking in the tablet. Is it just a sugar
• 13:21
  Speaker 2: pill or is it going to be or like a
• 13:23
  Speaker 2: plain pill whatever, or is it going to be the
• 13:24
  Speaker 2: health And then they had a wash out period. So
• 13:27
  Speaker 2: a wash out period is a period of time where
• 13:29
  Speaker 2: you're not taking anything. It often is around the two
• 13:31
  Speaker 2: week mark, but it depends on the study. So they
• 13:33
  Speaker 2: do the four weeks or just over four weeks, then
• 13:35
  Speaker 2: you got a wash out period of nothing. Then you
• 13:37
  Speaker 2: return back and you do another four weeks doing the
• 13:40
  Speaker 2: other one that you didn't do.
• 13:44
  Speaker 1: So they found that after four.
• 13:47
  Speaker 2: Weeks, stress symptoms went down, anxiety traits depressive threats also
• 13:51
  Speaker 2: went down, sleep quality improved.
• 13:52
  Speaker 1: They also found that cognitive function.
• 13:55
  Speaker 2: When tested on verbal fluency and executive function improved, which
• 13:58
  Speaker 2: is amazing.
• 13:59
  Speaker 1: And this this is just in four weeks.
• 14:02
  Speaker 2: So this is what two hundred milligrams of l phene
• 14:04
  Speaker 2: in over four weeks can do, which is extremely impressive.
• 14:07
  Speaker 2: So you could start by having one cup two cups
• 14:11
  Speaker 2: of green tea a day, one or two cups of
• 14:13
  Speaker 2: much a day and hopefully you're going to start really
• 14:17
  Speaker 2: noticing a difference. Now, if you don't like green tea
• 14:20
  Speaker 2: or much, you can have a supplement form.
• 14:23
  Speaker 1: Now, the supplements do tend to be.
• 14:26
  Speaker 2: A little bit exy because it's apparently quite difficult to
• 14:30
  Speaker 2: extract the lphenn and put it into supplement form, so
• 14:34
  Speaker 2: it's not the cheapest process. But look, if you like
• 14:37
  Speaker 2: green tea. If you're willing to force yourself to like it,
• 14:39
  Speaker 2: then that's going to be a much cheaper, very very
• 14:42
  Speaker 2: good alternative to the supplements. But supplements a day as
• 14:44
  Speaker 2: an option, and it's going to.
• 14:45
  Speaker 1: Give you the same benefits.
• 14:46
  Speaker 2: Okay, So fucking yes, that's the brain fact of today.
• 14:51
  Speaker 2: And I really hope that all of you that when
• 14:54
  Speaker 2: I release this brain fact last time, the obsession that
• 14:58
  Speaker 2: I had from everyone being like, oh, oh my fucking god,
• 15:00
  Speaker 2: I'm drinking green tea. Now I'm having much a tea
• 15:02
  Speaker 2: I'm having I'm doing the lth and out of all
• 15:04
  Speaker 2: the things you've told me to take, this is the
• 15:06
  Speaker 2: most exciting one. So I really have these high hopes
• 15:09
  Speaker 2: that I've got this big surge of excitement from you
• 15:13
  Speaker 2: guys to do this for your brain. You're not only
• 15:16
  Speaker 2: doing your brain a favor from the neuroprotective benefits, you're
• 15:19
  Speaker 2: doing your mood a favor.
• 15:21
  Speaker 1: You're doing your happiness a favor. It's just so fucking good.
• 15:24
  Speaker 2: I am the spokesperson for l A and and I
• 15:28
  Speaker 2: love it. Sense